Microneedling with Rejuran

Microneedling with Rejuran in Seattle

Skin naturally loses collagen, hydration, and elasticity over time, which is why fine lines, uneven texture, enlarged pores, and dull tone become more noticeable with age. Microneedling with Rejuran in Seattle is a combination treatment that pairs collagen-induction therapy with a regenerative polynucleotide treatment to support the skin’s own repair process.

Rejuran is formulated from purified polynucleotides (PN), fragments derived from salmon DNA that have a long history of use in regenerative medicine for supporting tissue repair. When applied immediately after microneedling, Rejuran can reach deeper into the skin through the temporary micro-channels created by the treatment, which may support collagen remodeling, hydration, and overall skin quality.

This approach may benefit patients dealing with acne scarring, early fine lines, textural irregularities, enlarged pores, or a generally dull or tired-looking complexion. Because every patient’s skin responds differently, treatment at Seattle Plastic Surgery begins with a personalized consultation to determine depth, protocol, and whether Rejuran should be added to the plan.

All treatment is provided under physician-directed care, with microneedling and Rejuran performed by an experienced Master Aesthetician when appropriate, working within a surgeon-led practice.

Quick Answer

Microneedling with Rejuran combines controlled micro-injury with a regenerative polynucleotide serum to support collagen production, tissue repair, and skin hydration. Most patients recover within 24–72 hours and notice gradual improvements in texture, tone, and firmness over the following weeks, with full results typically visible around 8–12 weeks after treatment.

Why Patients Are Combining Rejuran with Microneedling

Microneedling and Rejuran work through complementary mechanisms, making them a popular combination for patients seeking comprehensive skin rejuvenation. Microneedling creates controlled microchannels in the skin, triggering the body’s natural healing response and stimulating collagen and elastin production. These microchannels also allow Rejuran to penetrate more effectively into the skin.

Rejuran contains polynucleotides (PN), which support the skin’s natural repair process by promoting tissue regeneration, improving hydration, and strengthening the skin barrier. When used together, microneedling initiates collagen production while Rejuran helps optimize healing, creating an environment that supports smoother texture, improved elasticity, and healthier-looking skin.

What Is Rejuran?

Rejuran is a regenerative skin treatment formulated with purified polynucleotides (PN), DNA fragments derived from salmon and highly refined for medical aesthetic use. Rather than simply improving the skin’s surface, Rejuran is designed to support the skin’s natural repair process by encouraging tissue regeneration, improving skin quality, and promoting healthier-looking skin over time. For this reason, Rejuran is often used to address concerns such as fine lines, acne scars, uneven texture, and dull skin.

What Rejuran Is Not

Unlike other aesthetic treatments, Rejuran works by supporting skin regeneration rather than changing facial movement or adding volume.

• Rejuran is not a neuromodulator like Botox: It does not relax facial muscles or reduce dynamic wrinkles caused by muscle movement.
• Rejuran is not a dermal filler: It is not intended to restore lost facial volume or enhance facial contours.
• Rejuran is not a surgical procedure: It is a minimally invasive treatment that can be applied through injections or combined with microneedling to enhance product delivery.

Because Rejuran works through a different mechanism, it is often used alongside treatments such as Botox, dermal fillers, laser resurfacing, or microneedling as part of a comprehensive skin rejuvenation plan rather than as a replacement for them.

How Microneedling Works?

Microneedling uses a device with fine, sterile needles to create a controlled pattern of micro-injuries in the skin’s surface. This process, known as collagen induction therapy, prompts the body to respond as it would to any minor injury: by activating fibroblasts to produce new collagen and elastin.

Over the following weeks, this remodeling process can gradually improve firmness, texture, and the appearance of scarring. Because the changes are tied to the skin’s natural repair timeline, results build progressively rather than appearing right away.

Why Combine Rejuran with Microneedling?

This is where the science of the combination becomes clearer. Microneedling creates temporary channels in the skin’s outer layer. On their own, these channels support the skin’s collagen response. When Rejuran is applied immediately afterward, those same channels may allow for improved absorption of the polynucleotide solution into the upper layers of skin.

• Microneedling creates controlled channels 
• Improves topical absorption 
• Supports the healing process 
• May improve collagen remodeling 
• Healthier skin appearance

The intent is not to create two separate effects, but a single supported healing environment — one where collagen stimulation and tissue repair are addressed together rather than sequentially.

What are the Benefits of Microneedling with Rejuran?

What are the Conditions Treated by Microneedling with Rejuran?

Is Microneedling with Rejuran Right for You?

You may be a good candidate if you:

• Want to address acne scarring, fine lines, or uneven texture
• Are looking for a non-surgical way to support skin quality
• Want a treatment plan that can evolve alongside other aesthetic goals
• Are in good general health with no active skin infections

This treatment may not be appropriate if you:

• Are pregnant
• Have an active skin infection in the treatment area
• Have certain unmanaged skin conditions
• Have uncontrolled medical conditions
• Have used isotretinoin recently (to be evaluated on a case-by-case basis)
• Have a history of keloid scarring (requires individual evaluation)

A consultation with our team will help determine whether Microneedling with Rejuran in Seattle is appropriate for your skin and health history.

What Happens During Treatment?

Each session begins with a consultation to review skin concerns and confirm the treatment plan. The skin is then cleansed thoroughly, and a topical numbing cream is applied to improve comfort during the procedure. Once the skin is prepared, microneedling is performed across the treatment area, followed by application of Rejuran into the newly formed microchannels. A cooling step helps calm the skin, and detailed aftercare instructions are provided before the patient leaves.

What Does Recovery Timeline Look Like?

• First Day: Redness and sensitivity are expected, similar to a mild sunburn.
• Days 2–3: Redness typically softens and continues to fade.
• Week One: Surface healing is generally complete, and a subtle glow may begin to appear.
• Weeks 2–4: Collagen remodeling continues beneath the surface.
• Month Two: Texture and firmness improvements often become more noticeable.
• Month Three: Continued collagen maturation may bring further visible improvement.

Microneedling with Rejuran Before & After Care

Before Treatment, Avoid:

• Retinoids
• Exfoliating acids
• Sun exposure
• Self-tanning products

After Treatment, Use:

• A gentle, hydrating moisturizer
• Broad-spectrum sunscreen
• A mild, non-irritating cleanser

After Treatment, Avoid:

• Makeup for the recommended period
• Swimming
• Sauna or steam exposure
• Heavy workouts
• Harsh or exfoliating skincare products

Difference between Rejuran and other Injectors?

Cost of Microneedling with Rejuran at Seattle Plastic Surgery

At Seattle Plastic Surgery, Microneedling with Rejuran costs $800 per session in Seattle, which includes $300 for microneedling and $500 for Rejuran.

For patients planning a series of treatments, we also offer a package of three microneedling sessions at  a discounted price of $679 per session, with Rejuran available as an additional $500 per session.

During your consultation, our experienced aestheticians will evaluate your skin concerns, discuss your goals, and recommend a personalized treatment plan to help you achieve the best possible results.

Safety

As with any cosmetic treatment, individual results and side effects can vary. Commonly reported effects following microneedling with Rejuran include:

• Temporary redness
• Mild swelling
• Light bruising in the treated area

These effects typically resolve within a few days. Patients should contact the clinic if they experience signs of infection, prolonged or worsening swelling, unusual pain, or any reaction that doesn’t improve within the expected recovery window.

Why Choose Seattle Plastic Surgery?

Choosing the right provider is just as important as choosing the right treatment. At Seattle Plastic Surgery, Microneedling with Rejuran is performed using a personalized, surgeon-led approach designed to support safe treatment and natural-looking skin rejuvenation.

• Surgeon-led practice with oversight from board-certified plastic surgeons.
• Experienced Licensed Master trained under the guidance of board certified plastic surgeon
• Personalized treatment plans tailored to your skin type, concerns, and aesthetic goals.
• State-of-the-art facility equipped with advanced technology for aesthetic treatments.
• Comprehensive skin rejuvenation options if your treatment plan evolves beyond Microneedling with Rejuran.
• Focus on natural-looking results with healthier, smoother, and more radiant skin.
• Dedicated follow-up care to support your treatment journey and results.

FAQs

What is Rejuran?

Rejuran is a regenerative skin treatment made from purified polynucleotides derived from salmon DNA, designed to support tissue repair and overall skin quality.

What are polynucleotides?

Polynucleotides are purified DNA fragments that have been studied in regenerative medicine for their role in supporting cellular repair and tissue regeneration.

Is Rejuran FDA approved in the U.S.?

Rejuran is not currently FDA-approved as a standalone injectable treatment in the United States. Approval status varies by country and by specific product formulation.

How does Rejuran differ from fillers?

Fillers are designed to add volume beneath the skin. Rejuran does not add volume, it’s intended to support skin repair, hydration, and overall skin quality instead.

Does microneedling hurt?

Most patients tolerate the procedure well, especially with topical numbing applied beforehand. Sensations during treatment are typically described as mild pressure, vibration, or light prickling.

Is numbing cream used?

Yes, a topical numbing cream is applied before treatment to improve comfort during the procedure.

How long does recovery take?

Most patients experience 

24–72 hours of redness, mild swelling, or sensitivity before returning to their normal routine.

Can it improve acne scars?

Yes, many patients pursue this combination specifically to help soften the appearance of acne scarring through collagen remodeling support.

Can it treat melasma?

Microneedling and Rejuran are not primary treatments for melasma, and in some cases microneedling may not be appropriate for active melasma. This should be discussed during a consultation.

Can darker skin tones receive this treatment?

Many skin tones can be candidates for this treatment, though a consultation is important to assess individual risk factors, including the potential for post-inflammatory hyperpigmentation.

How many sessions are recommended?

This depends on your specific goals — some patients see benefit from a single session, while a series is often recommended for concerns like acne scarring or more pronounced texture issues.

How long do results last?

Results vary based on individual skin condition and maintenance, but many patients maintain improvements for several months with periodic follow-up treatments.

Is there downtime?

Yes, though it is generally brief, most patients experience 24–72 hours of visible redness and sensitivity.

Can men receive Rejuran?

Yes, Rejuran and microneedling combinations are suitable for men and women seeking to improve skin quality, texture, and hydration.

Can I exercise afterward?

It’s generally recommended to avoid strenuous exercise for at least 24 hours after treatment, since sweating and heat can irritate freshly treated skin.

Can I wear makeup after treatment?

Makeup is typically avoided for a short recommended period after treatment to support proper healing; your provider will confirm timing.

Can Rejuran be combined with laser treatments?

In some cases, yes, but this depends on individual assessment and appropriate timing between treatments, which your provider will determine.

Can I receive Botox after Rejuran?

Neurotoxin treatments can sometimes be combined with Rejuran, but the sequencing and timing should be evaluated individually by your provider.

What should I avoid before treatment?

Patients are generally advised to avoid retinoids, exfoliating acids, sun exposure, and self-tanning products in the days leading up to treatment.

What skincare products should I use afterward?

A gentle, non-irritating cleanser, a hydrating moisturizer, and broad-spectrum sunscreen are typically recommended following treatment.