Have you ever wished your skin could simply “reset” after sun damage, acne scars, or the first signs of fine lines? At Seattle Plastic Surgery, we now offer Salmon PDRN therapy—a regenerative option that may help your complexion look healthier, firmer, and better hydrated, with less recovery time compared to laser resurfacing.
What Exactly Is Salmon PDRN?
Salmon PDRN (polydeoxyribonucleotide) is a purified cocktail of DNA fragments derived from wild salmon. Remarkably, those fragments share approximately 97% genetic similarity with human DNA. First explored by Korean wound-care researchers, PDRN has now been injected for 30+ years with a strong safety record, but it is not FDA-approved in the United States and remains under review. Where most skin boosters simply add moisture or volume, PDRN acts like a set of “blueprints,” encouraging tired cells to rebuild healthy tissue from the inside out.
Benefits of Salmon PDRN for the Skin
Even though outcomes vary, peer-reviewed trials and in-house observations suggest several upsides:
- Plumper, more elastic skin: The DNA fragments can act like mini-sponges, drawing water in and nudging your cells to make fresh collagen. Many patients tell us their face simply feels “plumper” and looks dewier within a few weeks. [1]
- Softer fine lines and smoother texture: By strengthening the skin’s support layer, PDRN may blur tiny wrinkles and rough patches—especially around the eyes and mouth—so makeup glides on more easily.
- Brighter, more even tone: Early lab work hints that PDRN may dial down excess pigment, which can translate to fewer dark spots and a healthier overall glow. [2]
- Stronger, more resilient barrier: Regular sessions appear to reinforce the outer skin layers, so your complexion can handle Seattle’s damp winters and dry, sunny summers with less irritation. [3]
- Long-term skin resilience
Repeated sessions appear to strengthen the skin barrier, so your face can handle Seattle’s shifting weather with less dryness and irritation.
How Salmon PDRN Works Inside the Skin
Once micro-injected into the superficial dermis, PDRN can operate well below the surface, right inside the dermis, where collagen, elastin, and healing factors reside. Here’s a concise look at the mechanism:
Cell-to-cell activation
Micro-injected DNA fragments may “coach” sluggish fibroblasts to multiply and rebuild collagen and elastin—the very fibers that make skin look firm and springy.
Dermal water magnet
Polynucleotide chains draw and hold moisture while also encouraging natural hyaluronic-acid production, helping skin stay comfortably hydrated.
Inflammation modulation
PDRN interacts with adenosine A2A receptors and can dial down pro-inflammatory signals, which in turn may reduce post-treatment redness and swelling.
Faster, tidier repair
By boosting vascular endothelial growth factor (VEGF), the solution may speed micro-circulation and nutrient delivery, supporting quicker wound closure and smoother scar formation.
Barrier reinforcement
Regular sessions appear to thicken both the epidermal and dermal layers, leaving skin better equipped to handle environmental stressors such as wind, pollution, and UV exposure.
Are You an Ideal Candidate?
While an in-person visit helps you understand your situation better, Salmon PDRN works best for people who want noticeable renewal without a long recovery period. You may be a great match if you:
- Have fine lines, early laxity, or “crepey” texture.
- Struggle with lingering acne scars or large pores.
- Prefer a subtle, natural-looking improvement versus a voluminous filler look.
- Want to boost recovery after Fraxel®, CO₂ laser, or even summer sunburn.
- Do not have a severe fish allergy (PDRN is marine-derived).
Pregnancy, certain autoimmune disorders, or active skin infections may delay treatment; our medical team reviews every detail during the consultation.
Procedure Overview – What to Expect on Treatment Day
A Salmon PDRN session at Seattle Plastic Surgery feels more like a high-tech facial than a traditional injectable appointment. We block out roughly an hour so you never feel rushed, even though the needle time itself is brief.
Consultation & Suitability Check
First, we review your health history, recent procedures, and any active breakouts or rashes. Pregnancy, uncontrolled diabetes, and certain autoimmune skin conditions can raise the risk of side-effects, so we rule those out before scheduling. Global best-practice guidelines stress that choosing the right candidate is the single biggest factor in keeping treatments safe and effective.
Local Anesthesia & Skin Preparation
After double-cleansing with chlorhexidine or 70% alcohol, we apply a 4–7 % lidocaine cream under occlusion for 20–30 minutes. Most clients describe the injections that follow as little more than light pressure.
Micro-Papule Injection Technique
Using a 34–35 G needle held at a shallow 10° angle, our injector deposits micro-blebs (≈ 0.02–0.05 mL) about 0.5–1 cm apart within the superficial dermis. A flexible 25 G cannula may replace the needle along the mid-face or jawline to ensure even product distribution and fewer entry points.
Session Duration & Immediate Care
The actual injection phase takes about 15 minutes. We finish with a cooling mask—or sometimes a low-level LED light—to calm the skin, then apply a zinc-based sunscreen. Any redness or tiny papules usually subside by evening, allowing most people to head back to work or errands right away.
Recommended Treatment Course
Evidence-based protocols suggest a loading schedule of three sessions spaced 3–4 weeks apart, followed by a single maintenance booster approximately 6- 9 months later. Your personal plan may vary based on skin condition and goals.
Home After-Care
For the first 24 hours, skip makeup, saunas, retinoids, and vigorous workouts. Sleep with your head slightly elevated and apply SPF 30 + the next morning. Mild bruising or tenderness can occur but usually resolves within two to three days.
Recovery & After-Care
Tiny bumps (“meso-tags”) and pinkness fade within 4–24 hours. To maximize comfort and results, we usually recommend:
- Cool compresses the first night.
- Fragrance-free cleanser and moisturizer.
- Mineral SPF—and yes, even on cloudy Seattle days.
- Skip intense exercise, steam rooms, and retinoids for 48 hours.
We’ll text-check on you the next morning and invite you back at week three for the next session.
Contact Us
Cost & Financing
Pricing per session usually aligns with mid-tier dermal fillers; exact numbers depend on treated surface area and whether we combine modalities. Flexible financing plans are available through CareCredit® and other lending partners, so you can structure payments around your lifestyle and budget.
Safety & Possible Side Effects
Because PDRN is ultra-purified, allergic reactions are uncommon, and the most frequent side effects include short-term redness, pinpoint bruising, or mild swelling. We maintain emergency protocols and always review your medical history to minimize risk.
Why Choose Seattle Plastic Surgery?
At Seattle Plastic Surgery, our top physician-led team delivers evidence-backed treatments in a boutique setting just minutes from Pike Place and South Lake Union. We pair a fully accredited procedure suite with warm, one-on-one guidance, tailoring every Salmon PDRN session to your skin’s exact needs and checking in long after you leave, so advanced regeneration feels safe, transparent, and genuinely comfortable.
Schedule Your Salmon PDRN Consultation
Ready to explore regenerative skin care that may help you look refreshed without a lengthy recovery? Call 206-739-0355 or click here to reserve your personalized Salmon PDRN assessment today.
FAQs
What is PDRN salmon?
Salmon PDRN is a skin-boosting solution made from purified fragments of salmon DNA. These tiny DNA pieces can signal your skin to repair itself and build new collagen.
What does PDRN do for your skin?
It may hydrate deeper layers, smooth fine lines, improve elasticity, and support faster healing after cosmetic procedures. Results vary from person to person.
How many sessions of PDRN?
Most people start with 3–4 sessions spaced about three weeks apart, then book a maintenance booster every six to nine months.
How much does PDRN cost?
Pricing is similar to mid-range The exact cost depends on the number of vials and sessions required, so we provide a personalized quote during your consultation.
What are the side effects of PDRN?
Expect mild redness, tiny bumps, or light bruising that usually fades within a day or two. Severe reactions are rare but can include swelling or infection.
STILL HAVE QUESTIONS?
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