Polynucleotide (PDRN), derived from salmon DNA, has become a cornerstone in regenerative and aesthetic medicine. With its unique molecular structure, PDRN helps stimulate cell growth, repair damaged tissues, and restore youthful skin function. At Seattle Plastic Surgery, patients experience the advanced healing and rejuvenating effects of Salmon PDRN in Seattle and Tacoma through scientifically backed treatments designed to enhance skin recovery and overall vitality.
What Is PDRN and How It Works
PDRN (polydeoxyribonucleotide) is a biologically active compound extracted from the DNA of salmon sperm. It interacts with adenosine A2A receptors, triggering cellular regeneration and angiogenesis (new blood vessel formation). This enhances oxygen supply to tissues and accelerates the healing process.
Its pharmacological activity lies in promoting DNA synthesis, which rejuvenates skin cells and boosts collagen production. The result is improved texture, elasticity, and wound healing — making PDRN a highly effective treatment for post-surgical recovery, scarring, and skin aging.
Key Pharmacological Benefits of PDRN
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Tissue Regeneration – PDRN stimulates fibroblast activity, encouraging collagen remodeling and rapid tissue repair.
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Anti-Inflammatory Action – By activating the adenosine A2A receptor, it helps reduce inflammation and oxidative stress.
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Enhanced Blood Circulation – Promotes angiogenesis, improving nutrient delivery to the skin.
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Improved Skin Hydration – Restores moisture balance by strengthening the skin barrier and increasing hyaluronic acid production.
These properties make PDRN treatments in Seattle a sought-after option for patients seeking non-surgical rejuvenation or post-procedural recovery support.
Clinical Applications of PDRN
Clinically, PDRN is used across multiple fields — from dermatology and wound healing to aesthetic medicine. It’s applied through mesotherapy, microneedling, or IV infusions, depending on the therapeutic goal.
At Seattle Plastic Surgery, Salmon PDRN therapy is utilized to:
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Rejuvenate photoaged or sagging skin
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Support recovery after laser resurfacing or facial surgery
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Improve acne scars and hyperpigmentation
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Boost healing in chronic wounds or burns
Recent studies have confirmed that PDRN enhances tissue oxygenation, DNA repair, and cell proliferation, leading to visible skin improvement and faster recovery outcomes.
Why Choose Seattle Plastic Surgery for PDRN Treatments
Under the guidance of experienced medical professionals, Seattle Plastic Surgery offers personalized PDRN protocols that combine clinical expertise with advanced regenerative solutions. Each treatment is designed to deliver optimal hydration, smoothness, and collagen restoration tailored to individual skin needs.
Restore. Rejuvenate. Renew.
Discover the power of Salmon PDRN in Seattle and Tacoma and experience science-backed skin rejuvenation like never before.
Call (206) 324-1120 or use our Price Simulator to plan your treatment today.

Dr. Jonov is a cosmetic surgeon who specializes in plastic surgeries of the face, breast, and body at Seattle Plastic Surgery.